The Hepatitis D Virus (HDV) Database, HDVdb contains comprehensive data on HDV genetic sequences that allows the researchers to investigate the genetic variability of the virus. The HDV database strives to present HDV-associated sequences,as well as providing access to the central database via web-accessible search interfaces and supplying a number of analysis tools.
HDV Information
Taxonomy: Group V ((-)ssRNA); Family Unassigned; Deltavirus; Hepatitis D virus
Virion: 36 nm, spherical and enveloped
Genome: 1.68 kilobase circular, single-stranded RNA
Proteome: single ORF codes for two isoforms, S-HDAg (195aa) and L-HDAg (214aa)
Infection: initiates by HBsAg protein interacting with cell surface heparan sulfate proteoglycans
Transmission: infects humans via sexual contact, blood, maternal-neonatal
Phylogeny: 8 distinct genotypes identified
Epidemiology: 15 to 20 million infected worldwide
Associated Diseases: Fulminant acute hepatitis, severe chronic active hepatitis, hepatocellular carcinoma
Vaccine: Vaccine against HBV protects also from HDV
Treatment: The current Interferon treatment has little effect on elimination of HDV in chronic infections
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The current HDVdb was updated on 24.04.2020 and has the following enteries:
1. L-HDAG and S-HDAG = 1066
2. Complete genomes = 512
3. Partial sequences = 1281
Search Database
Please use the following search by filter methods below to download filtered datasets. Alternatively complete dataset can be downloaded directly from the download page.
Input Example:
Please write the search query in following format:
For Country write only: "Country_name" for example --> Germany
For Accession write GenBank accession number only: for example --> MH457150
or multiple sequences as comma separated --> MH457149,MH457150
For Date write: Year_From-Year_To for example --> 2005-2020
for only one year please write 2010-2010
For Genotype write: Genotype Number, for example --> Genotype 3
Note: Please make sure to follow the above syntax for search. Alternately, full datasets can be downloaded from Download section.
Note: Please note that partial sequences are not extensively annotated and therefore Genotype, Country, and Date is not available for all of the sequences.